FRANK A. BEACH AWARD IN BEHAVIORAL NEUROENDOCRINOLOGY
Initiated 1990 Awarded to an assistant professor (Announced annually in Fall/Winter)
SBN’s New Investigator Award is named in Frank Beach’s honor, a tribute both to his scientific accomplishments and to his teaching and mentorship of graduate students and postdoctoral fellows. Frank Beach was the principal founder of behavioral endocrinology: He named and defined the discipline (Beach, 1975), wrote the first survey (Beach, 1948) and history (Beach, 1981) of the field, organized the annual West Coast sex conference, which eventually morphed into the SBN, and founded the journal Hormones and Behavior.
CALL FOR NOMINATIONS
Nominations are now being accepted for the 31st Annual Frank A. Beach New Investigator Award in Behavioral Neuroendocrinology. The deadline for submitting nominations is September 27th, 2020.
2020 Award Winner: Stephanie Correa, PhD
Dr. Correa received her Ph.D. in Neurobiology and Behavior from Cornell University. Her doctoral research with Dr. Elizabeth Adkins-Regan studied the effects of ovarian steroids on offspring sex ratios in birds. As a postdoc with Dr. Kenn Albrect at Boston University Medical Center, Dr. Correa studied testis development in mice and identified alleles that compromise testis development in the C57BL/6 genetic background. She then continued her postdoctoral training with Dr. Holly Ingraham at the University of California, San Francisco, combining endocrine and genetic manipulations to identify estrogen-sensitive neurons in the hypothalamus that promote physical activity and maintain normal body weight in female mice. Throughout her training, Dr. Correa was funded by an NSF Graduate Research Fellowship, two Cornell University fellowships, an NIH NRSA Institutional Postdoctoral Training Grant, an American Heart Association Postdoctoral Fellowship, and an NIH K01 Mentored Scientist Career Development Award.
Since joining the faculty at the University of California, Los Angeles in 2015, Dr. Correa has established an innovative and extramurally funded research program dissecting cells and gene programs that mediate the effects of estrogens on temperature and energy balance. Research in the Correa Lab seeks to understand the changes associated with menopause and identify new neuronal or genetic targets that could be used to stabilize metabolism or thermoregulation without systemic hormone therapy. The lab’s first publication, a collaboration with the Ingraham Lab at UCSF, identified a powerful role for kisspeptin neurons in regulating bone growth in female mice. These studies continue in the Ingraham lab and may lead to new treatments for osteoporosis. In studies started at UCLA, the Correa Lab identified ERa neurons that regulate temperature in mice. These neurons co-express ERa and Reprimo, a cell cycle regulating and estrogen-responsive gene. Reprimo is highly expressed in the VMH of females and essentially off in males, a sex difference that is established by ERa signaling early in life. Reprimo knockdown alters temperature in females but not males. If applicable to humans, this study presents a gene candidate for stabilizing temperature without systemic estrogen therapy.
Recent studies extend Dr. Correa’s research to the medial preoptic area (MPA) and the effects of tamoxifen on the hypothalamus. The Correa Lab found that activating ERa neurons in the MPA of mice is sufficient to trigger torpor, a hypothermic and hypometabolic state induced in response to food scarcity. Fasting-induced torpor alters the activity of ERa MPA neurons and killing ERa neurons prohibits the full expression of torpor, linking these neurons to natural torpor. A new line of research seeks to model tamoxifen therapy for breast cancer in mice and understand the effects of this drug on thermoregulation, bone health, and movement. Single cell RNA sequencing reveals widespread transcriptional effects of chronic tamoxifen administration on the hypothalamus. Surprisingly, knocking out ERa in the hypothalamus ablates both the physiological and transcriptional effects of tamoxifen treatment. This study provides a mouse model and possible mechanisms for understanding and potentially mitigating the side effects of tamoxifen therapy.
In addition to these pioneering discoveries, Dr. Correa has secured R01 and R21 grants from NIH, has an outstanding track record of mentorship, is active in diversity and inclusion efforts on behalf of UCLA and SBN, and recently joined the Editorial Board for Hormones and Behavior.
Previous winners of the Frank A. Beach New Investigator Award are:
||Stephanie Correa, PhD
||Ben Dantzer, PhD
||Zoe R. Donaldson, PhD
||Hormones and Behavior Volume 126, November 2020, 104869
||Hormones and Behavior Volume 114, August 2019, 104521
||Hormones and Behavior Volume 107, January 2019, Pages 67-75
||Sari van Anders
||Hormones and Behavior 2014, 66 (3), 552-560
||Hormones and Behavior, 2013, 63 (5), 684-691
||Hormones and Behavior, 2011, 60 (5), 457-469
||Frances Anne Champagne
||Hormones and Behavior, 2011, 60, 4-11
||Hormones and Behavior, 2010, 58, 555-62
||Hormones and Behavior, 2008, 54, 227-33
||Hormones and Behavior, 2007, 52, 561-70
||Hormones and Behavior, 2006, 50, 655-666
||James L. Goodson *
||Hormones and Behavior, 2005, 48, 11-22
||Brian Prendergast *
||Hormones and Behavior, 2005, 48, 503-511
||Tracy L. Bale
||Hormones and Behavior, 2005, 48, 1-10
||Gregory E. Demas *
||Hormones and Behavior, 2004, 45, 173-180
||Anthony P. Auger *
||Hormones and Behavior, 2004, 45, 168-172
||Joseph S. Lonstein
||Hormones and Behavior, 2003, 42, 258-262
||A. Courtney DeVries
||Hormones and Behavior, 2002, 41, 405-413
||Lique M. Coolen
||Hormones and Behavior, 2010, 58, 149-162
||Larry J. Young
||Hormones and Behavior, 1999, 36, 212-221
||Hormones and Behavior, 1998, 34, 320-327
||Ruth I. Wood
||Hormones and Behavior, 1997, 32, 40-45
||Horm Behav. 1996 Sep;30(3):187-200.
||Margaret McCarthy *
||Horm Behav. 1995 Jun;29(2):131-40.
||Laura Smale *
||Horm Behav. 1995 Jun;29(2):127-30.
||Horm Behav. 1994 Sep;28(3):191-8.
||Horm Behav. 1993 Mar;27(1):1-4.
||Horm Behav. 1992 Mar;26(1):1-6.
||Emilie F Rissman
||Horm Behav. 1991 Jun;25(2):125-7